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non-Hodgkin lymphoma (NHL): From UniSci - Daily University Science News Children who have been exposed to household insecticides and professional extermination methods within the home are three to seven times more likely to develop non-Hodgkin lymphoma (NHL) compared with children who have not been exposed to pesticides. These are the results of a study published in the December 1 issue of the journal CANCER, an international publication of the American Cancer Society. The study indicated that a child's risk of developing NHL was similar for both maternal exposure to pesticides during pregnancy (in utero) and direct (postnatal) exposure to pesticides. Significant variations in risk were associated with various NHL morphologies. For instance, the use of household insecticides increased the risk of lymphoblastic lymphoma by 12.5 times. The term "pesticides" refers to a group of chemicals that have in common their ability to kill insects, plants, mammals (particularly rodents), or fungi. "A limited number of these compounds may be capable of inducing lymphoma, particularly when used around the home," comments chief researcher Jonathan D. Buckley, M.B.B.S., Ph.D., from the Department of Preventative Medicine at the University of Southern California in Los Angeles. Lymphoma, the third most common childhood malignancy, occurs at a rate of 21.7 per million in children age < 15 years. Approximately 60% of these cases are NHL. In the current study, the Children's Cancer Group evaluated the correlation between home pesticide use or occupational exposure to pesticides and the incidence of NHL in a pediatric study sample. The study included children and adolescents age < 20 years who were diagnosed with NHL between February 1986 and June 1990. ... (Reference: "Pesticide Exposures in Children with Non-Hodgkin Lymphoma," Jonathan D Buckley, M.B.B.S., Ph.D., Anna T. Meadows, M.D., Marshall E. Kadin, M.D, Michelle M. Le Beau, Ph.D., Stuart Siegel, M.D., and Leslie L. Robison, Ph.D., CANCER 2000; 89:11.) [Contact: [3]Anna Radev] 3. mailto:aradev@wiley.com 30-Nov-2000 2. http://unisci.com/
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