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20/08/23/2003

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CHEMICAL - ARSENIC
Arsenic's fatal legacy grows worldwide

http://www.newscientist.com/news/news.jsp?id=ns99994024

http://www.noccawood.ca

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CHEMICALS - LEAD

 Even low lead levels pose perils for children

New York Times.  You have no doubt heard of similar situations in the past. A substance known  to be hazardous above a certain level is deemed safe below that, only to discover years later that the so-called safe level was not safe at all. Such has  repeatedly been the case with children's exposure to lead, a substance known since 1923 to damage the brain.  http://www.nytimes.com/2003/08/05/health/nutrition/05BROD.html

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CHEMICALS – PHTALATES

2003-08-13 Intake of plasticisers possibly higher than assumed
BfR deems review of ongoing risk assessment of DEHP required on the European level

Plasticisers keep plastic products pliant. They are used in so many areas of daily life that they can be described as ubiquitous. The consumer, therefore, frequently comes into contact with these substances. One of the most frequently used plasticisers is diethyl hexyl phthalate, in short DEHP. This substance is considered to be "well investigated" in terms of its health risk. A comprehensive risk assessment is currently being undertaken within the framework of the European existing chemicals programme. Despite the damaging effects which DEHP can trigger, more extensive, risk-reducing measures are only deemed to be necessary for children but not for adults. This is justified by the fact that the estimated average daily intake of DEHP is within the tolerable dose range. BfR has now challenged this assessment and bases its arguments on the new study findings from the University of Erlangen. According to these findings, the daily DEHP intake may be far higher than assumed up to now. An important and, up to now underestimated, source could be food. BfR has drawn the attention of the European Chemicals Bureau (ECB) to the new study results and requested a review of the assessment particularly with regard to the reprotoxic effect of DEHP. According to the Institute this could lead to a new assessment of the risk with corresponding repercussions for the need for exposurereducing measures.

DEHP belongs to the group of phthalates. It has a low acute toxicity; the substance is not classified as mutagenic. Depending on the dose, DEHP may have damaging effects on the testicles, kidneys and liver. In animal experiments the substance impairs reproductive capacity and leads to congenital abnormalities of the sexual organs in male offspring. DEHP is used in the production of a large range of plastic products, mainly PVC materials. The substance is present, for instance, in car parts (panelling, controls), clothing, toys, food packaging, cosmetics and medical devices (dialysis tubes). Because of its physical properties DEHP can dissolve or outgas when it comes into contact with liquids or fats from plastics and then directly reach the consumer or indoor air. The European existing substance report states that the average daily intake of DEHP through respiratory air, skin and blood is 12 microgram per kilogram body weight and day (µg/kg body weight/day). This value is far lower than the tolerable daily intake of 50 µg/kg body weight/day, laid down by the EU Scientific Committee for Food, at which no damage to health is to be expected. However, the food path was not taken into account when assessing the exposure of the consumers in the existing substance report.

Study findings of the University of Erlangen now seem to indicate that this could have led to a significant underestimation of the actual intake level. There they examined urine samples from 85 participants for levels of DEHP degradation products and calculated an intake level which was far higher than that given in the existing substance report for some of the test persons. For 5% of the participants it was higher than 52.1 µg/body weight/day. The authors suspected food exposed to DEHP as the source. As between 50 and 70% of DEHP is resorbed in the gastro-intestinal tract, this exposure route could contribute to a major degree to DEHP intake. The Institute, therefore, believes it is necessary to identify and reduce the main sources of exposure.

The Federal Institute for Risk Assessment has drawn the attention of the European Chemical Bureau to the results of the study and requested a review of the ongoing risk assessment. As DEHP is not only the plasticiser with the largest production volume but possibly also with the severest reprotoxic effect, this could lead to a new assessment of the risk and, by extension, to a need for minimisation measures. The only national application restrictions for DEHP in the food sector are those within the framework of the plastics recommendations of BfR. Furthermore, the Institute has recommended that no phthalates be used in toy manufacture.

Further information on DEHP can be accessed on our homepage only in German (www.bfr.bund.de ) under "Lebensmittel" (Lebensmittelsicherheit/Rückstände und Kontaminanten)

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CHEMICALS – PESTICIDES

Beyond Pesticides' Daily News Headlines (week of August 18-22, 2003) Full stories available at  www.beyondpesticides.org/main.html .

    * NRDC Sues EPA for Failing to Protect Endangered Wildlife from Atrazine

    * Recycling Plant Workers Poisoned by Pesticide

    * Toxic Pesticides Found in California Rain Samples

    * Program Launched to Incorporate Organic Food At School and Home

    * Judge Favors Pesticide-Free Zones on Some West Coast Salmon Streams

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Beyond Pesticides' Daily News Headlines (week of August 11-15, 2003) Full stories available at http://www.beyondpesticides.org/main.htm

- Borates Used Successfully As Alternative to Highly Toxic Wood Preservatives

- Report Weighs Risks and Benefits of DDT

- School and Childcare IPM Programs Significantly Reduce Pesticide Use And Pest Problems

- Michigan's Bald Eagles Soar Due to DDT Ban

- Pesticide Tracking Law Stalls in Oregon

The purpose of this update is to let you know about pesticide news stories  posted at  http://www.beyondpesticides.org/main.html from the past week that you might have missed. These updates will be short  and sent only once a week. If you know of a story that should be covered in  the Daily News, please let us know by sending an email to info@beyondpesticides.org.

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From P A N U P S Pesticide Action Network Updates Service

Indian Pop Has POPs (and other pesticides)

August 15, 2003

The Centre for Science and Environment (CSE) in India reported on August 5, 2003 that pesticides had been found in twelve brands of Indian soft drinks. CSE's Pollution Monitoring Laboratory (PML) analyzed samples of bottled soft drinks for 16 organochlorine pesticides, 12 organophosphorus pesticides and 4 synthetic pyrethroides, all of which are used extensively in India. The soft drink brands tested were Blue Pepsi, Coca-Cola, Diet Pepsi, Fanta, Limca, Mirinda Orange, Mirinda Lemon, Mountain Dew, Pepsi, Sprite, Thums Up and 7-Up.

Lindane, an organochlorine pesticide applied to seeds before planting and used pharmaceutically to treat lice and scabies, was found in every brand of soft drink tested. Lindane persists in the environment, contaminates surface and ground water and accumulates in fat tissues. Highest concentrations of lindane found by PML were 0.0042 mg/L, or 42 times the European Economic Commission (EEC) standard for drinking water. For all twelve brands, lindane concentrations averaged 21 times the EEC standard. …

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Resource Pointer #333 (Water Pollution), August 20, 2003

Resource Pointer #332 (Children's Environmental Health), August 13, 2003

Resource Pointer #331 (Debt and Development in the Global South), August 6, 2003

Back issues of PANUPS are available online at: http://www.panna.org/resources/panups.html

Pesticide Action Network North America (PANNA), Email: panna@panna.org Web: http://www.panna.org

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 CONSUMERS

U.S. Department of Health and Human Services NATIONAL INSTITUTES OF HEALTH, NIH News National Library of Medicine http://www.nlm.nih.gov/

August 1, 2003 Household products database New Information Service Provides Information On Health and Safety of Everyday Products

BETHESDA, MARYLAND -- The National Institutes of Health today unveiled a consumer's guide that provides easy-to- understand information on the potential health effects of more than 2,000 ingredients contained in more than 4,000 common household products.

Some household products contain substances that can pose health risks if they are ingested or inhaled, or if they come in contact with eyes and skin. The National Library of Medicine's (NLM) Household Products Database (http://householdproducts.nlm.nih.gov) provides information in consumer friendly language on many of these substances and their potential health effects. For more technical information users can launch a search for a product or ingredient in TOXNET from the Product Page in the database.

Information in the database is provided to NLM under a collaborative agreement and is derived from publicly available sources, including brand-specific labels and information provided by manufacturers and their Web sites. The list of products covered will be expanded, and information for products currently in the database will be updated at least annually.

"The Household Products Database is a natural outgrowth of the work that the Library has done in recent years, educating the public about environmental risks posed by chemicals in the air, soil and water," explained NLM Director Dr. Donald A.B. Lindberg. "Last year, we unveiled Tox Town (http://toxtown.nlm.nih.gov), a site that introduces consumers to the toxic chemicals and environmental risks they might encounter in everyday life, in everyday places. Tox Town looks at facilities like schools, office buildings and factories, and the chemicals likely to be in them. With the Household Products site, we go inside the user's home and provide information about common products and their potential health effects."

The Household Products Database enables users to learn what's in the products under the kitchen sink, in the garage, in the bathroom, and on the laundry room shelf. It is designed to help answer questions such as:

-- What chemicals are contained in specific brands and in what percentage?

-- Which products contain specified chemicals?

-- Who manufactures a specific brand? How can I contact the manufacturer?

-- What are the potential health effects of the chemical ingredients in a specific brand?

-- What other information is available about such chemicals in the toxicology-related databases of the National Library of Medicine?

For example, a homeowner trying to decide which algae- killing product to use in her swimming pool could select the "Landscape/Yard/Swimming Pool" category in Household Products and click on "algaecide." She then could choose several brands to examine for chemical content and possible health hazards.The record for each product would show her the ingredients from something called the Material Safety Data Sheet (MSDS). Designed to provide workers and emergency personnel with the proper procedures for handling or working with a particular substance, these sheets are produced by the manufacturer of the product as required by Federal law. NLM Associate Director for Specialized Information Services, Dr. Jack Snyder, said, "NLM has provided animportant set of databases for toxicologists and other scientists for many years. The target audience of the Household Products Database, however, is both scientists and the general public. The database allows users to browse a product category, such as 'Pesticides' or 'Personal Care,' by alphabetical listing or by brand name. Products can also be searched by type, manufacturer, product ingredient, or chemical name.

Located in Bethesda, Maryland, the National Library of Medicine, the world's largest library of the health sciences, is a component of the National Institutes of Health, Department of Health and Human Services 

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POLITIC- EU - PUBLIC HEALTH

 - Injury prevention

Injury prevention programme newsletter http://europa.eu.int/comm/health/ph_determinants/environment/IPP/newsletter_ipp_en.htm

Issue 10 (PDF, 286 KB) http://europa.eu.int/comm/health/ph_determinants/environment/IPP/documents/ippnewsletter10.pdf

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POLITIC - USA

Spoon-Feeding Poison

US EPA Opens the Door to Testing Bug Killers on People

 The Bush administration is now moving to endorse the testing of noxious and lethal chemicals on human beings. Since this spring, despite rife opposition from the medical community, the Environmental Protection Agency has quietly begun lifting a 1998 ban on accepting such research. Once the prohibition is gone, which will likely happen next year, chemical companies will have the full support of the federal government to dose healthy young men and women with the latest insecticides, rodenticides, and fungicides.

This marks the second round in a fiery debate over pesticide tests using people. In the late 1990s, a group of doctors and public health advocates noticed that pesticide companies were conducting a growing number of these trials as part of attempts to get government approval. The advocates railed against the EPA and balked at the agency's failure to enforce ethical standards. The "EPA does not routinely require companies who conduct human experiments to . . . follow any ethical protocol," noted a 1998 report from the Environmental Working Group.

Later that year, with criticism mounting, the agency prohibited its offices from using human data in new pesticide registrations. Some companies continued the testing, however, saying it was necessary to determine health risks. But they also preferred that method because they got more favorable readings from dosing people as opposed to lab rats.

The tests appear to defy the very essence of the Hippocratic oath, "First, do no harm." Unlike tests for exploratory vaccines and medicines, pesticide studies offer zero benefits for participants. They're designed to find the level at which concoctions of orange juice and bug spray won't send people crawling toward death, and are considered a glowing success only when nothing happens. Independent researchers say the tests' scientific value is highly suspect.

But there's big money at stake, especially with the EPA considering new restrictions or outright bans on a number of products. On March 31, the Office of Management and Budget, the White House's rule review board, signed off on a rough draft of a new policy that would again allow the EPA to accept the test results.

Doctors, environmentalists, and public health advocates have been fighting the change. When the EPA first took up the idea, medical experts began to pore over a stack of human tests. They found many of the studies were cloaked in claims of valid research but were dominated by practices that belonged in the annals of medical farce. "A reasonable person might conclude that they were specifically designed to fail to show effects of the pesticides," said Dr. Alan Lockwood, a member of Physicians for Social Responsibility and a neurology professor at the State University of New York at Buffalo.

Vermin killers have a nasty history. In 1934, Nazi Germany whipped up the first batch of pesticides—organophosphates, in scientific parlance—for use as a chemical weapon. Although the toxic soup never made it to the front lines, I.G. Farben, the company that manufactured it (today Bayer, BASF and Aventis), found it could be marketed as bug sprays and rodent zappers.

Today, big chemical companies are fans of human research because it encourages less stringent standards. With data from lab animals, the EPA assumes the predicted hazards for humans would be greater by a factor of 10. It's called the "inter-species rule," adopted by Congress to account for potential differences between reactions in, say, a two-year-old child and a mature lab rat. Testing on humans lets a company duck the automatic increase.

That translates directly into several billion dollars for the pesticide industry, which annually sells nearly 4.5 billion pounds of chemicals—at a profit of more than $6 billion. Manufacturers have an outsized financial incentive to push for testing on humans, warned Dr. Lynn Goldman, the EPA's pesticide director under President Clinton and now a professor at the Johns Hopkins Bloomberg School of Public Health. "EPA must of course be mindful at all times of the test sponsors' interests in performing tests and, of course, of the almost overwhelming economic incentives that companies have to find ways to market more of their products," she said in January, testifying before the National Academy of Sciences.

Critics say the companies give sparse attention to decent testing procedures and that nearly every aspect of the testing seems driven by the need to get EPA approval.

Take, for example, a 1999 test conducted by the Lincoln, Nebraska-based MDS Harris Laboratory. A handful of subjects were administered Dow Chemical's chlorpyrifos, a direct descendant of Hitler's nerve agents. MDS Harris had recruited the group of healthy young men and women by assuring them their health would be preserved, and by handing out juicy compensation checks. They were told in consent agreements that low doses of chlorpyrifos "have been shown to improve performance on numerous tests of mental function," implying that the chemical could propel them into a new realm of genius. "The consent process was inadequate, deceptive, or both," Dr. Lockwood said. "This makes it sound like chlorpyrifos is good for you and may make you smarter—a clear deception."

Nevertheless, when none of them died, fainted, or delivered farewell speeches while clutching their hearts in agony, Dow submitted a glowing report of the pesticide to the EPA and eagerly awaited registration approval. Just one year later, on June 8, 2000, the EPA determined that chlorpyrifos, a widely employed pesticide, posed an "unreasonable threat" and said residential uses should be expeditiously restricted.

In another experiment, conducted in 1997 at the Central Toxicology Laboratory, researchers gave oral doses of dichlorvos, a common insecticide, to a group of six young men. When four of them suffered a dangerous drop in vital enzyme levels, they had to withdraw from the test. With only two subjects able to complete the doses, the Central Toxicology Laboratory announced that "no symptoms or adverse effects . . . were reported." They skirted the fact that two-thirds of the participants had to drop out and effectively asserted that the results derived from two people adequately reflected the potential harm to 266 million U.S. citizens.

And there is potential harm. Pesticides eat away at an enzyme called cholinesterase, which plays a key role in all physical movement. It sweeps away chemical debris between nerve cells, allowing those cells to fire up to 1,000 electric impulses to each other every second. Pesticides break down cholinesterase, leaving millions of chemical messages to clog the works. In mild cases, this leads to nausea, sweating, uncontrollable drooling, headaches, and vomiting. In severe cases, it causes muscular tremors, abnormally low blood pressure, loss of bowel functions, slowed heart rates, and even death.

But test groups rarely get that sick. And that's no surprise, considering their size and make-up. They're usually limited to between six and 50 people, typically young and healthy adults who are paid anywhere from $300 to $1,000. The studies are advertised in local newspapers or on college campuses, specifically targeted to attract people from low-income or minority communities.

Pesticide companies insist that trying out their wares on you and your neighbors allows idiosyncratic human reactions to surface. "These safety factors are necessary," said Ray McAllister, vice president for science and regulatory affairs for CropLife America, a lobbying group representing 41 corporations, including Dow, DuPont, and Monsanto. "If we don't know how humans react, then we can't be confident of safety."

The industry is lining the campaign coffers on Capitol Hill. In the five years since the EPA stopped looking at human research, the Center for Responsive Politics reports, companies providing agricultural services and products donated more than $20 million to political campaigns, almost 70 percent of which went to Republicans. by Tennille Tracy, Village Voice, July 9 - 15, 2003

Coalition against BAYER-dangers www.CBGnetwork.org,  CBGnetwork@aol.com

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POLITIC - USA

US House of Representatives: Government Reform Committee, Minority Staff 

*   Manipulation of Scientific Committees

 *  Distortion of Scientific Information

 *  Interference with Scientific Research

Website   Overview

The American people depend upon federal agencies to develop science-based policies that   protect the nation's health and welfare. Recently, however, leading scientific journals have begun to   question whether scientific integrity at federal agencies has been sacrificed to further a political and ideological agenda.

At the request of Rep. Henry A. Waxman, the minority staff of the Government Reform Committee  (of the U.S. House of Representatives) assessed the treatment of science and scientists by the Bush Administration.

The report Politics and Science in the Bush Administration (.pdf) finds numerous instances where the Administration has manipulated the scientific process and distorted or supressed scientific findings. Beneficiaries include important   supporters of the President, including social conservatives and powerful industry groups.

 This website is an ongoing record of interference with science by the Bush Administration.

Note links to: Environmental Health - Advisory Committee to CDC's National Center on Env Health

Lead Advice to CDC -- Politics Triumphs Over Appointments to CDC's Lead Advisory Group

Workplace Safety -- Tampering with NIOSH Study Section

Agricultural Pollution -- USDA Censors Publishing of Scientific Research by Scientists

Breast Cancer - Changing an Analysis by the National Cancer Institute

Perchlorate in Drinking Water - Pentagon drops Perchlorate Testing Program

http://www.house.gov

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RACHEL'S ENVIRONMENT & HEALTH NEWS.

July 10, 2003 (Published August 15, 2003)  # 773 The revolution, pt 2

June 26, 2003 (Published August 12, 2003)  # 772 The revolution, pt 1

June 12, 2003 (Published August 7, 2003)     #771 Subsidizing the destruction of the commons

May 29, 2003 (Published July 31, 2003        #770  Environmental justice and precaution   

www.rachel.org

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SMOKE and DUST

Smoke and Dust at World Trade Center Is Linked to Smaller Babies

By ANDREW C. REVKIN

Scientists say they have measured a slight but significant rise in the  percentage of small babies born to women who were around the World Trade Center

during or after the terror attack compared with babies of a large sample of  pregnant women who were elsewhere at the time.The researchers, from the Mount Sinai  School of Medicine, proposed that air pollution from the pulverized, smoldering  wreckage was the most likely cause of the difference. But they and other

experts said more work is needed to clarify any link.     http://www.nytimes.com/2003/08/06/nyregion/06BABY.html

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end of newslettter /English/20

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